Assessment of the endocrine-disrupting effects of organophosphorus pesticide triazophos and its metabolites on endocrine hormones biosynthesis, transport and receptor binding in silico.
作者： Fang-Wei Yang , Yi-Xuan Li , Fa-Zheng Ren , Jie Luo , Guo-Fang Pang
DOI: 10.1016/J.FCT.2019.110759
关键词:
摘要: Triazophos (TAP) was a widely used organophosphorus insecticide in developing countries. TAP could produce specific metabolites triazophos-oxon (TAPO) and 1-phenyl-3-hydroxy-1,2,4-triazole (PHT) non-specific diethylthiophosphate (DETP) diethylphosphate (DEP). The objective of this study involved computational approaches to discover potential mechanisms molecular interaction its major with endocrine hormone-related proteins using docking silico. We found that TAP, TAPO DEP showed high binding affinity more enzymes than PHT DETP. might interfere the function adrenal gland, also bind strongly glucocorticoid receptors thyroid hormone receptors. disrupt normal androgen receptor, estrogen progesterone receptor adrenergic their natural ligands. affect biosynthesis steroid hormones hormones. Meanwhile, transport blood These results suggested have disrupting activities were chemicals. Our provided further reference for comprehensive evaluation toxicity chemicals metabolites.
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