Chagas disease in the immunosuppressed patient.

摘要: This review addresses relevant aspects of Chagas disease in the immunocompromised host. disease—one world's most neglected diseases—has become a global public health concern. Novel transmission modalities, such as organ transplantation, evidence parasite persistence chronically infected individuals—with potential for reactivation under immunosuppression—and prolonged survival immunosuppressed patients call an appraisal this particular setting. The management and outcome solid transplantation recipient with special focus on heart is addressed. guidelines recipients organs from donors are discussed, comments haematopoietic stem cell included. Finally, other situations impairment immune system, HIV/AIDS autoimmune diseases, considered. Immunosuppression has increasingly frequent condition that might modify natural history Trypanosoma cruzi infection. A number strategies available patient. First, according to recent recommendations authorities Argentina, would benefit being treated at diagnosis. not been validated different immunosuppressive disorders. strategy involve treating only documented (either parasitaemia or clinical manifestations). These approaches discussed. To reach diagnosis parasitaemia, monitoring essential, either conventional methods molecular techniques yet all centres. Collaborative studies needed improve level evidence, which will allow better guidelines.