Fertility and Pregnancy Outcome After Abdominal Irradiation That Included or Excluded the Pelvis in Childhood Tumor Survivors

摘要: Purpose To evaluate fertility after abdominal and/or pelvic irradiation in long-term female survivors. Methods and Materials Puberty pregnancy outcome were analyzed survivors of childhood cancer (aged Results A total 84 patients who had received RT during alive aged more than 18 years at the time study made up population. Of 57 treated with that excluded pelvis, 52 (91%) progressed normally through puberty 23 (40%) least one recorded pregnancy. 27 RT, only 10 (37%) 5 (19%) Twenty-two women (seventeen whom RT) certain subfertility. 50 births occurred 28 women, baby dying birth; miscarriage also occurred. There was a high prevalence prematurity low birth weight but not congenital malformations. Conclusions Fertility can be preserved undergo excludes taking into account other treatments (e.g., chemotherapy alkylating agents) are taken account. When includes is frequently impaired have difficulty conceiving. Nevertheless, pregnancies occur some these women. The most important factor endangers successful dose by ovaries uterus. This radiation has to systematically improve our ability follow patients.