Transcription factors and cognate signalling cascades in the regulation of autophagy

摘要: Autophagy is a process that maintains the equilibrium between biosynthesis and recycling of cellular constituents; it critical for avoiding pathophysiology results from imbalance in homeostasis. Recent reports indicate need design high-throughput screening assays to identify targets small molecules autophagy modulation. For such screening, however, better understanding regulation essential. In addition by various signalling cascades, gene expression transcription factors also critical. This review focuses on as well corresponding act together translate stimuli effector up- or downregulate autophagy. rationalizes importance these functioning tandem with cognate their interfaces possible therapeutic more specific pharmacological interventions.