Control of insulin receptor affinity by a Ca2+-sensitive binding site
作者： P WILLIAMS , I CATERSON , J TURTLE
DOI: 10.1016/0304-4165(84)90378-7
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摘要: Calcium (Ca2+) increased insulin-receptor binding in both membrane and solubilised receptor preparations. Ca2+ affinity initial rate of association [125I]insulin to the had no effect on insulin number either preparation. The could be mimicked by ions with similar ionic radii properties (e.g., Ba2+, Mg2+ Sr2+). EDTA oleic acid reduced these effects were reversed addition Ca2+. These studies suggest that Ca2+-like may bind a site or near responsible for conformational change consequent increase affinity.
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