The multifaceted activity of VEGF in angiogenesis – Implications for therapy responses

摘要: Vascular endothelial growth factor (VEGF) is a key driving angiogenesis (i.e. the formation of new blood vessels) in health and disease. Pharmacological blockade VEGF signaling to inhibit tumor clinically approved but survival benefit limited as patients invariably acquire resistance. This partially mediated by intrinsic flexibility cells adapt VEGF-blockade. However, it has become clear that stromal also contribute Originally, was thought specifically target (ECs) now many respond signaling, making anti-VEGF therapy more complex than initially anticipated. A comprehensive understanding responses VEGF-blockade might inform design improved anti-angiogenic agents.