Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.
作者： Michele De Palma , Mary Anna Venneri , Rossella Galli , Lucia Sergi Sergi , Letterio S. Politi
DOI: 10.1016/J.CCR.2005.08.002
关键词:
摘要: Bone marrow-derived cells contribute to tumor angiogenesis. Here, we demonstrate that monocytes expressing the Tie2 receptor (Tie2-expressing [TEMs]) (1) are a distinct hematopoietic lineage of proangiogenic cells, (2) selectively recruited spontaneous and orthotopic tumors, (3) promote angiogenesis in paracrine manner, (4) account for most activity myeloid tumors. Remarkably, TEM knockout completely prevented human glioma neovascularization mouse brain induced substantial regression. Besides TEMs endothelial (ECs), expression distinguished rare population stroma-derived mesenchymal progenitors representing primary source pericytes. Therefore, characterizes three cell types required neovascularization: ECs, origin, pericyte precursors origin.
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