A novel alloantigen on rat macrophages and granulocytes.

摘要: Previous studies have shown that immunization of MAXX rats with spleen and lymph node cells from the MHC-identical BN strain results in formation antibodies react renal endothelial alloantigen Eag-1. In present study, reactivity anti-BN sera was further characterized. No antisera detected unseparated spleen, node, thymus bone marrow cell suspensions, peripheral blood, or obtained lung lavages. The did, however, splenic macrophages, as well peritoneal granulocytes macrophages BN, BMA, BN.1L, PVG rats. Genetic revealed antigen, provisionally designated Pag-1, segregates independently Eag-1, RT1 complex, sex, hooded albino traits. Pag-1 appears to be absent kidney, since absorption kidney homogenates did not remove against raised bind endothelium. is expressed on marrow-derived cells, lethally irradiated were reconstituted donors reacted sera, whereas not.