Chagas Cardiomyopathy in the Context of the Chronic Disease Transition

摘要: Background Patients with Chagas disease have migrated to cities, where obesity, hypertension and other cardiac risk factors are common. Methodology/Principal Findings The study included adult patients evaluated by the cardiology service in a public hospital Santa Cruz, Bolivia. Data for T. cruzi infection, medical history, physical examination, electrocardiogram, echocardiogram, contact 9 months after initial data collection ascertain mortality. Serology PCR Trypanosoma were performed. Of 394 participants, 251 (64%) had confirmed infection serology. Among seropositive 109 (43%) positive results conventional PCR; of these, 89 (82%) also real time PCR. There was high prevalence overweight (body mass index [BMI] >25; 67%), no difference status. Nearly 60% symptomatic congestive heart failure attributed cardiomyopathy; mortality higher than seronegative (p = 0.05). In multivariable models, longer residence an endemic province, rural area poor housing conditions associated infection. Male sex, increasing age independent predictors cardiomyopathy severity. Males participants BMI ≤25 significantly likelihood compared females or participants. Conclusions Chagas remains important cause this population, should be context epidemiological transition that has increased chronic cardiovascular disease.