Renal Cortical Mitochondria Are the Source of Oxygen Free Radicals Enhanced by Gentamicin
作者： Chao-Ling Yang , Xue-Hai Du , Yong-Xin Han
DOI: 10.3109/08860229509036371
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摘要: Rat renal cortical mitochondria were isolated from Wistar male rats weighing 80 to 120 g investigate whether the source of oxygen free radicals was enhanced by gentamicin. In with or without addition gentamicin, DMSO, DFO, CAT, SOD, and MTl added separately, then incubated at 37°C for 90 min. Superoxide anions hydroxyl determined. The results showed that superoxide generated in vitro gentamicin (12.4 mg/mL) when compared those Dimethylsulfoxide (DMSO), catalase (CAT), deferoxamine (DFO) significantly inhibited but dismutase (SOD) metallothionein-1 (MTl) did not. SOD production anions. Our data indicated are is ...
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