FATIGUE COUNTERMEASURES FOR RAPID DEPLOYMENT: OPERATION PEGASUS

摘要: Abstract : The aim of this work was to investigate the effects slow-release caffeine (SRC) and melatonin (MLT) on sleep daytime vigilance SRC or MLT as chronobiotics after a 7-time zone eastbound flight. Three groups 9 US Air Force reservists each received either five daily doses (300 mg), four nightly (5 mg) appropriate placebo for in double-blind, randomized manner. Nighttime evaluated by polysomnography Multiple Sleep Latency Tests (MSLT) continuous wrist actigraphy. Cognitive function assessed computerized tests from AGARD-NATO STRES Battery. Attention also with symbol cancellation task Stroop test alertness gauged visual analogue scale (VAS). All but nighttime neuroendocrine samples were performed two blocks, during AM PM. Core temperature continuously measured safety treatment repeated clinical examinations. Saliva urine sampled before flight United States baseline (from Day -2 0) France 1 10). collected once day waking determine saliva cortisol concentrations. addition, concentrations determined three times 6-sulphatoxymelatonin upon awakening.