Plasma copeptin level predicts acute traumatic coagulopathy and progressive hemorrhagic injury after traumatic brain injury

摘要: Abstract Higher plasma copeptin levels correlate with poor clinical outcomes after traumatic brain injury. Nevertheless, their links acute coagulopathy and progressive hemorrhagic injury are unknown. Therefore, we aimed to investigate the relationship between levels, in patients severe We prospectively studied 100 consecutive presenting within 6 h from head trauma. Progressive was present when follow-up computerized tomography scan reported any increase size or number of lesion, including newly developed ones. Acute defined as an activated partial thromboplastic time greater than 40 s and/or international normalized ratio 1.2 a platelet count less 120 × 109/L. measured on admission using enzyme-linked immunosorbent assay blinded fashion. In multivariate logistic regression analysis, level emerged independent predictor coagulopathy. Using receiver operating characteristic curves, calculated areas under curve for The predictive performance similar that Glasgow Coma Scale score. However, did not obviously improve value Thus, may help prediction