L-Diphenylalanine Microtubes As a Potential Drug-Delivery System: Characterization, Release Kinetics, and Cytotoxicity

摘要: Microtubes obtained from the self-assembly of L-diphenylalanine (FF-MTs) were evaluated as potential vehicles for drug delivery. The biological marker Rhodamine B (RhB) was chosen a model and conjugated to peptide arrays during self-organization in liquid phase. Microscopy X-ray studies performed provide morphological structural information. data revealed that cargo distributed either small aggregates at hydrophobic surface FF-MTs or homogeneously embedded structure, presumably anchored polar sites matrix. Raman spectroscopy notable shifts characteristic RhB resonance peaks, demonstrating successful conjugation fluorophore assemblies. In vitro assays conducted erythrocytes fibroblast cells. Interestingly, found modulate release load. followed first-order kinetics with steady-state profile, these carriers deliver drugs constant rates body. Cytotoxicity investigations high cell viability up concentrations 5 mg mL(-1), low toxicity FF-MTs.