Effects of caffeine on the frequencies of chromosomal aberrations and sister chromatid exchanges induced by chemical mutagens in root tips of Vicia faba
作者： B. A. KIHLMAN , S. STURELID
DOI: 10.1111/J.1601-5223.1978.TB01599.X
关键词:
摘要: Lateral roots of Vicia faba were grown for one cell cycle in the presence 5-bromodeoxyuridine (BrdUrd) and then another thymidine. Between BrdUrd thymidine treatments exposed 1 or 2 hours to following substances: MMS, EMS, MNNG, quinacrine mustard, mitomycin C, thiotepa, bleomycin maleic hydrazide. All these agents produced chromosomal aberrations and, with exception bleomycin, strongly increased frequency sister chromatid exchanges (SCEs). The addition caffeine solution resulted a strong increase frequencies induced by substances, but had no significant effect on SCEs. This suggests that SCEs are mechanisms at least partly different.
sci-hub.se 参考文章(27)
B. A. Kihlman, Sister chromatid exchanges in Vicia faba Chromosoma. ,vol. 51, pp. 11- 18 ,(1975) , 10.1007/BF00285802
Bengt A. Kihlman, Caffeine and chromosomes ,(1977)
Yukimasa SHIRAISHI, Avery A. SANDBERG, Caffeine and Sister Chromatid Exchange Proceedings of the Japan Academy. ,vol. 52, pp. 379- 382 ,(1976) , 10.2183/PJAB1945.52.379
Hatao Kato, Spontaneous and Induced Sister Chromatid Exchanges as Revealed by the BUdR-Labeling Method International Review of Cytology-a Survey of Cell Biology. ,vol. 49, pp. 55- 97 ,(1977) , 10.1016/S0074-7696(08)61947-6
HATAO KATO, Spontaneous sister chromatid exchanges detected by a BUdR-labelling method Nature. ,vol. 251, pp. 70- 72 ,(1974) , 10.1038/251070A0
K. Hayashi, W. Schmid, The rate of sister chromatid exchanges parallel to spontaneous chromosome breakage in Fanconi's anemia and to trenimon-induced aberrations in human lymphocytes and fibroblasts. Human Genetics. ,vol. 29, pp. 201- 206 ,(1975) , 10.1007/BF00297624
Ellen Solomon, Martin Bobrow, Sister chromatid exchanges—A sensitive assay of agents damaging human chromosomes Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. ,vol. 30, pp. 273- 277 ,(1975) , 10.1016/S0027-5107(75)80013-3
Hatao Kato, Mechanisms for sister chromatid exchanges and their relation to the production of chromosomal aberrations. Chromosoma. ,vol. 59, pp. 179- 191 ,(1977) , 10.1007/BF00292776
P. Perry, H. J. Evans, Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange. Nature. ,vol. 258, pp. 121- 125 ,(1975) , 10.1038/258121A0
HATAO KATO, Possible role of DNA synthesis in formation of sister chromatid exchanges Nature. ,vol. 252, pp. 739- 741 ,(1974) , 10.1038/252739A0