Gametes and embryo epigenetic reprogramming affect developmental outcome: implication for assisted reproductive technologies

摘要: There is concern about the health of children who are conceived with use assisted reproductive technologies (ART). In addition to reports low birth weight and chromosomal anomalies, there evidence that ART may be associated increased epigenetic disorders in infants using these procedures. Epigenetic reprogramming critical during gametogenesis at preimplantation stage involves DNA methylation, imprinting, RNA silencing, covalent modifications histones, remodeling by other chromatin-associated complexes. regulation involved early embryo development, fetal growth, weight. Disturbances lead developmental problems mortality. Recent suggest incidence imprinting such as Beckwith-Wiedemann syndrome, Angelman retinoblastoma ART. These result from an accumulation alterations culture and/or altered embryonic timing. Further research urgently needed determine whether a causal relationship between exists. Until then, cautious review both short-term long-term outcomes national level recommended.