Brain Cancer Stem Cells as Targets of Novel Therapies

作者: Jennifer M. Atkinson , Richard J. Gilbertson , Jeremy N. Rich

DOI: 10.1007/978-1-60327-553-8_44

关键词:

摘要: The cancer stem cell hypothesis posits that tumors are heterogeneous in their composition and contain a population of neoplastic cells display sustained self-renewal, proliferative potential, the capacity for tumor propagation. significance clinical practice remains undefined but laboratory studies have identified specific signaling pathways niches may offer new therapeutic avenues. Characterizing also inform improved brain prognosis imaging.

参考文章(100)
Amy H. Yin, Sheri Miraglia, Esmail D. Zanjani, Graca Almeida-Porada, Makio Ogawa, Anne G. Leary, Johanna Olweus, John Kearney, David W. Buck, AC133, a Novel Marker for Human Hematopoietic Stem and Progenitor Cells Blood. ,vol. 90, pp. 5002- 5012 ,(1997) , 10.1182/BLOOD.V90.12.5002
Christine E. Eyler, Wen-Chi Foo, Katherine M. LaFiura, Roger E. McLendon, Anita B. Hjelmeland, Jeremy N. Rich, Brain Cancer Stem Cells Display Preferential Sensitivity to Akt Inhibition Stem Cells. ,vol. 26, pp. 3027- 3036 ,(2008) , 10.1634/STEMCELLS.2007-1073
Qi Li, Millicent C. Ford, Erin B. Lavik, Joseph A. Madri, Modeling the neurovascular niche: VEGF- and BDNF-mediated cross-talk between neural stem cells and endothelial cells: An in vitro study Journal of Neuroscience Research. ,vol. 84, pp. 1656- 1668 ,(2006) , 10.1002/JNR.21087
Qin Shen, Susan K Goderie, Li Jin, Nithin Karanth, Yu Sun, Natalia Abramova, Peter Vincent, Kevin Pumiglia, Sally Temple, Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells Science. ,vol. 304, pp. 1338- 1340 ,(2004) , 10.1126/SCIENCE.1095505
Elaine Fuchs, Tudorita Tumbar, Geraldine Guasch, Socializing with the Neighbors: Stem Cells and Their Niche Cell. ,vol. 116, pp. 769- 778 ,(2004) , 10.1016/S0092-8674(04)00255-7
Tatyana N. Ignatova, Valery G. Kukekov, Eric D. Laywell, Oleg N. Suslov, Frank D. Vrionis, Dennis A. Steindler, Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia. ,vol. 39, pp. 193- 206 ,(2002) , 10.1002/GLIA.10094
A Eramo, L Ricci-Vitiani, A Zeuner, R Pallini, F Lotti, G Sette, E Pilozzi, L M Larocca, C Peschle, R De Maria, Chemotherapy resistance of glioblastoma stem cells Cell Death & Differentiation. ,vol. 13, pp. 1238- 1241 ,(2006) , 10.1038/SJ.CDD.4401872
Carmen Ramírez-Castillejo, Francisco Sánchez-Sánchez, Celia Andreu-Agulló, Sacri R Ferrón, J Daniel Aroca-Aguilar, Pilar Sánchez, Helena Mira, Julio Escribano, Isabel Fariñas, Pigment epithelium–derived factor is a niche signal for neural stem cell renewal Nature Neuroscience. ,vol. 9, pp. 331- 339 ,(2006) , 10.1038/NN1657
Rakesh K. Jain, Emmanuelle di Tomaso, Dan G. Duda, Jay S. Loeffler, A. Gregory Sorensen, Tracy T. Batchelor, Angiogenesis in brain tumours Nature Reviews Neuroscience. ,vol. 8, pp. 610- 622 ,(2007) , 10.1038/NRN2175
Jeongwu Lee, Myung Jin Son, Kevin Woolard, Nicholas M. Donin, Aiguo Li, Chui H. Cheng, Svetlana Kotliarova, Yuri Kotliarov, Jennifer Walling, Susie Ahn, Misuk Kim, Mariam Totonchy, Thomas Cusack, Chibawanye Ene, Hilary Ma, Qin Su, Jean Claude Zenklusen, Wei Zhang, Dragan Maric, Howard A. Fine, Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell. ,vol. 13, pp. 69- 80 ,(2008) , 10.1016/J.CCR.2007.12.005