d-Cycloserine improves sociability in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders with altered Ras/Raf/ERK1/2 signaling

摘要: Abstract The genetically inbred BTBR T+ Itpr3tf/J (BTBR) mouse is a proposed model of autism spectrum disorders (ASDs). Similar to several syndromic forms ASDs, mTOR activity may be enhanced in this strain as result increased Ras signaling. Recently, d -cycloserine, partial glycine B site agonist that targets the NMDA receptor, was shown improve sociability Balb/c strain, another ASDs. receptor activation an important regulator signaling activity. Given ability -cycloserine and regulatory role signaling, we wondered if would impaired strain. -Cycloserine (320 mg/kg, ip) improved measures standard paradigm spontaneous grooming emerged during social interaction with ICR stimulus strain; however, similar effects were observed Swiss Webster comparator raising questions about their strain-selectivity. Importantly, profile -cycloserine’s on both stereotypies consistent desired medication for ASDs; specifically, not at expense worsening stereotypic behaviors or vice versa.