Platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) tyrosine phosphorylation state changes during vasculogenesis in the murine conceptus.

摘要: Vasculogenesis, the differentiation of mesodermal cells to angioblasts and subsequent formation blood islands vessels by in conceptus, is a dynamic process modulated, part, cell-extracellular matrix cell-cell interactions presence variety growth factors morphogens. In this report we demonstrate differential tyrosine phosphorylation platelet-endothelial cell adhesion molecule-1 (PECAM-1) during from clusters extraembryonic embryonic murine conceptus. addition, identify particular residue PECAM-1 cytoplasmic domain, Tyr686, which has potential mediating binding Src homology 2 domain-containing proteins, affecting cellular localization endothelial migration.