PECAM-1 (CD31) functions as a reservoir for and a modulator of tyrosine-phosphorylated beta-catenin.

摘要: Catenins function as regulators of cellular signaling events in addition to their previously documented roles adherens junction formation and function. Evidence date suggests that beta gamma catenins can act molecules, bind transcriptional factors translocate the nucleus. Beta- gamma-catenin are also major substrates for protein tyrosine kinases, phosphorylation junctional proteins is correlated with decreased adhesiveness. One way which catenin functions modulated by dynamic incorporation into complexes controls, part, cytoplasmic levels catenins. Here we show that: (1) vascular endothelial growth factor (VEGF) induces beta-catenin a time-, dose-dependent manner VEGF receptors co-localize areas cell-cell contact vitro vivo. (2) Platelet-endothelial cell adhesion molecule (PECAM)-1 reservoir for, modulator of, phosphorylated beta-catenin. (3) PECAM-1 prevent nuclear translocation transfected SW480 colon carcinoma cells. We suggest may play role modulating levels, localization doing so, an important endothelium.