Profound effects of cardiopulmonary bypass priming solutions on the fibrin part of clot formation: an ex vivo evaluation using rotation thromboelastometry.

摘要: Objectives Dilutional coagulopathy as a consequence of cardiopulmonary bypass (CPB) system priming may also be affected by the composition solution. The direct effects distinct solutions on fibrinogen, one foremost limiting factors during dilutional coagulopathy, have been minimally evaluated. Therefore, authors investigated whether hemodilution with different distinctly affects fibrinogen-mediated step in whole blood clot formation. Design Prospective observational laboratory study. Setting University hospital laboratory. Participants Eight male healthy volunteers. Interventions Blood samples diluted gelatin-, albumin-, or hydroxyethyl starch (HES)-based were ex-vivo evaluated for formation rotational thromboelastometry. Measurements and Main Results intrinsic pathway (INTEM) coagulation time increased from 186 ± 19 seconds to 205 16, 220 17, 223 18 after dilution HES-containing prime (all p Conclusions All studied prolonged decreased formation, but fibrinogen-limiting effect was most profound These results suggest that affect particular respect fibrinogen component hemostasis.