Overview of Molecular Diagnostics in Clinical Pathology

摘要: Molecular diagnostics has expanded medical genomics in a major way. assays complement results obtained from serology, microbiology, and hematology tests. They provide supplemental information to anatomical pathologists for the diagnosis classification of cancers. Oncologists use mutation analysis molecular select first-line therapy cancers rely on specialized tests prognostic assessment residual tumor cells that may still be present very small amounts after – minimal disease. Infectious disease specialists diagnosis, monitoring, therapeutic management patients. Clinical geneticists depend data screening inherited rare diseases. Technologically advanced interrogate an array genetic variants microorganisms panel-like interpretation host genome diseases steer clinicians toward personalized approach patient management. This technology-driven discipline utilizes principle complementarity amplify, hybridize, sequence DNA. Development, verification, validation as well training personnel testing are critical establishing performance characteristics diagnostics.