BMPs as new insulin sensitizers: enhanced glucose uptake in mature 3T3-L1 adipocytes via PPARγ and GLUT4 upregulation.
作者： Isabelle Schreiber , Gina Dörpholz , Claus-Eric Ott , Bjørt Kragesteen , Nancy Schanze
DOI: 10.1038/S41598-017-17595-5
关键词:
摘要: Insulin-resistance is the main cause of type 2 diabetes. Here we describe identification and characterization BMP2 BMP6 as new insulin-sensitizing growth factors in mature adipocytes. We show that lead to enhanced insulin-mediated glucose uptake both insulin-sensitive -insensitive exclude a direct effect or on translocation GLUT4 plasma membrane demonstrate these BMPs increase protein levels equipotent Rosiglitazone. induce expression PPARγ crucial mediator for effect. A comprehensive RNA-Seq analysis adipocytes revealed regulation BMP/Smad target genes. The effects are not completely redundant include genes involved fatty acid metabolism adipokine expression. Collectively, findings suggest pathway(s) promising drug targets treat insulin resistance.
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