Anti-inflammatory properties of bone morphogenetic protein 4 in human adipocytes.

摘要: Background Obesity is characterized by increased adipocyte number and size as well white adipose tissue (WAT) inflammation, which fundamental for the development of insulin resistance type-2 diabetes. These processes, regulated various endocrine, paracrine autocrine factors, are extensively studied with hope to interfere inhibit weight gain related complications in obese patients. Recent data suggest an important role bone morphogenic protein 4 (BMP4) regulation adipogenesis obesity. BMP4 a growth factor transforming factor-β superfamily. Initially, BMPs were identified inducers ectopic formation. It now apparent, however, that these proteins have different pleiotropic developmental actions including playing adipogenesis. Methods results Here, we demonstrate expression human WAT negatively correlated body mass index pro-inflammatory cytokines. In vitro, cultured adipocytes upregulated after induction differentiation. Cells treated exogenous peroxisome proliferator-activated receptor γ (PPARγ) significantly reduced cytokines tumor necrosis α (TNF-α) monocyte chemoattractant 1. TNF-α treatment fully differentiated resulted downregulation adipogenic genes elevated Exogenous addition negative effect on profile adipocytes. Finally, adipocytes' potential migration monocytes toward adipocyte-conditioned medium. Conclusions indicate anti-inflammatory molecule, may act through PPARγ reduces TNF-α-mediated cytokine production Through its potential, serve protective inflammation-related diseases such insulin-tolerance or