Gene polymorphisms of stress hormone and cytokine receptors associate with immunomodulatory profile and psychological measurement.

摘要: Abstract Objective We sought to identify whether stable single nucleotide polymorphisms (SNPs) of various endocrine and immune molecules could be used as biomarkers associated with specific alterations chronic stress measures in normal humans. Methods A total 207 volunteer participants answered questionnaire gave peripheral blood cells for identification SNPs genes coding glucocorticoid receptor (GR), beta 2 adrenergic (B2AR), interferon-gamma receptors (IFNGR1, IFNGR2), interleukin-4 (IL4R). Immunoregulatory profiles were measured by flow cytometry genotyping assays performed allelic discrimination real-time PCR. Results Several significant differences revealed associations between marker indicators based on SNP categories. For instance, Th1 levels the minor alleles GR TthIIII (AA) IFNGR2 Q64R (Arg/Arg) groups positively (PSS) ( p  = 0.024 0.005, respectively) compared wild type (WT) negatively PSS heterozygous genotypes BclI IL4R Ile50Val  = 0.040  = 0.052, respectively). Treg (GG) IFNGR1 T-56C (CC)  = 0.045  = 0.010, allele (Val/Val) Ile50Va genotype Q576R  = 0.041  = 0.017, WT. Conclusion The data support notion that gene from components psychoneuroendocrine-immune network may useful categorize individual stress-associated responses.