Roles of host and bacterial virulence factors in the development of upper urinary tract infection caused by Escherichia coli

摘要: Abstract Aims of this study are to identify host and Escherichia coli virulence factors associated with upper urinary tract infection (UTI) by comparing them those for lower UTI determining the association between major predisposing urovirulence genes E . Host bacteremia in patients their interactions also were studied. One hundred thirty-nine adult who fulfilled clinical diagnostic criteria (n = 81) or 58) caused January 1997 December 1999 retrospectively enrolled into study. Old age (≥60 years), male sex, diabetes poor blood glucose control (ie, glycosylated hemoglobin A 1C ≥ 8.1%), immunosuppression, obstruction more frequently than UTI. Using polymerase chain reaction, papG class II allele was detected strains isolated from (85% versus 52%; P independently For without these three factors, prevalence significantly greater However, less prevalent two factors. In addition, both univariate multivariate analyses showed that old risk development conclusion, contribute UTI, virulent can cause hosts © 2002 National Kidney Foundation, Inc.