Fibroblast Growth Factors Stimulate Hair Growth through β-Catenin and Shh Expression in C57BL/6 Mice
作者： Wei-hong Lin , Li-Jun Xiang , Hong-Xue Shi , Jian Zhang , Li-ping Jiang
DOI: 10.1155/2015/730139
关键词:
摘要: Growth factors are involved in the regulation of hair morphogenesis and cycle growth. The present study sought to investigate growth promoting activities three approved factor drugs, fibroblast 10 (FGF-10), acidic (FGF-1), basic (FGF-2), mechanism action. We observed that FGFs promoted by inducing anagen phase telogenic C57BL/6 mice. Specifically, histomorphometric analysis data indicates topical application induced an earlier prolonged mature phase, contrast control group. Moreover, immunohistochemical reveals induction β-catenin Sonic hedgehog (Shh) follicles FGFs-treated These results suggest promote resting might be a potential growth-promoting agent.
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