Effects and metabolism of hormones in normal and neoplastic prostate tissue.

作者: Peter Ofner

DOI: 10.1016/S0083-6729(08)60756-6

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摘要: Publisher Summary This chapter discusses the effects and metabolism of hormones in normal neoplastic prostate tissue. The focuses on recent work fine structure tissue, hormonal influences specific glandular constituents, effect viable tissue culture prostatic steroid catabolism, a discussion human neoplasia its rodent canine counterparts. It is now becoming apparent that maintenance function residual epithelial activity castrate depends complex competitive or synergistic action sex steroids, corticoids, prolactin end organ. “Biological titration” with estrogen–androgen combinations has shown administration both required to maintain morphological integrity epithelium weight gland. Dihydrotestosterone 5α-androstane-3α,l7 β-diol, major products reductive catabolism testosterone prostate, their 17-ketosteroid analogs may be active androgens

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