Axons regulate Schwann cell expression of the POU transcription factor SCIP

摘要: SCIP (suppressed cAMP-inducible POU) is a POU domain transcription factor expressed by Schwann cells. Drugs that elevate intracellular cAMP, such as forskolin, increase the expression of and partially mimic inductive effects axons on cell gene expression. Thus, may be involved in differentiation pathway cells activated axons. We have examined this issue studying developing, degenerating, regenerating rat peripheral nerves, cell-neuron cocultures. High levels mRNA were detected developing axotomy at these times caused level to plummet. Similarly, there many SCIP-immunoreactive nuclei their number fell sharply after axotomy. associated with These data demonstrate upregulate cells, ensheathe mediate some changes accompany axonal ensheathment.