Selective room temperature phosphorescence detection of heparin based on manganese-doped zinc sulfide quantum dots/polybrene self-assembled nanosensor.
作者： Zhifeng Zhang , Yanming Miao , Qindi Zhang , Linwang Lian , Guiqin Yan
DOI: 10.1016/J.BIOS.2015.01.053
关键词:
摘要: Abstract A selective system was developed to detect heparin in aqueous solutions by using MPA(3-Mercaptopropionic Acid)-capped Mn-doped ZnS quantum dots (QDs)/polybrene (hexadimethrine bromide) hybrids as a sensitive room temperature phosphorescence (RTP) nanosensor. In this system, the RTP intensity of QDs remarkably enhanced via electrostatic self-assembly after addition polybrene. The into competitively bound polybrene and enable deprive it from surface QDs, result, QDs/polybrene reduced with increased concentration. Based on effect, proposed heparin. Under optimal conditions, change proportional concentration 0.05 1.4 U mL−1 (about 0.38–10.76 μg mL−1) limit detection (LOD) 0.021 U mL−1 0.16 μg mL−1). This nanosensor is simple relatively free interference coexisting substances, which can be applied injection human serum. addition, new pathway also provided based assembly other cationic homopolymers for further design biosensors biomolecules.
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