Off–on phosphorescence assay of heparin via gold nanoclusters modulated with protamine
作者： Shou-Nian Ding , Chun-Mei Li , Ning Bao
DOI: 10.1016/J.BIOS.2014.09.024
关键词:
摘要: A sensitive and selective phosphorescence "turn-off-on" nanosensor to detect heparin by gold nanoclusters (Au-NCs) modulated with protamine was developed. The carboxyl groups on the surface of Au-NCs can interact amino in via electrostatic interactions hydrogen bonding induce aggregation Au-NCs, which results photoluminescence "turn-off". However, presence heparin, prefers combine release "turn-on". lifetime measurements demonstrate that belongs phosphorescence, quenching progress is dynamic. concentration be determined measuring recovery. linear response range obtained from 0.006 25.0 μg mL(-1) detection limit 6 ng mL(-1). Moreover, proposed used fetal bovine serum samples satisfactory results.
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