Genetic factors affecting drug disposition in Asian cancer patients

摘要: Introduction: In the era of genomic medicine, it is increasingly recognized that ethnogeographic differences in drug pharmacology exist between Asian and other populations. This particularly pertinent to oncology, where drugs forming backbone chemotherapy often have narrow therapeutic windows are frequently dosed close maximally tolerable levels.Areas covered: At population level, ancestry important because historical–biogeographical confluences shaped genetics pharmacoethnicity race through allelic differentiation interethnic inheritance patterns linkage disequilibrium. individual cis- trans-acting germline polymorphisms somatic mutations genes encoding drug-metabolizing enzymes transporters act a multifactorial manner determine disposition phenotype clinical response cancer patients. A growing body evidence also finds complex genetic interactions regulation, inc...