First case report of Muir–Torre syndrome associated with non-small cell lung cancer

摘要: The eponymous Muir–Torre syndrome (MTS) is a clinical variant of hereditary non polyposis colorectal cancer, and defined as an autosomal dominant condition with simultaneous sebaceous neoplasms the skin visceral malignant disease resulting from germline mutations in DNA mismatch repair (MMR) genes. To date most common malignancy described which seen approximately 50% cases. Other clearly associated tumours include endometrial adenocarcinomas, urothelial transitional cell carcinomas, upper gastrointestinal adenomas ovarian (often mucinous) carcinomas. Here we report first recorded case adenocarcinoma lung loss MMR gene function to be identified patient MTS. deficient tumour demonstrated less aggressive behaviour compared synchronous proficient adenocarcinoma.