Evaluation of radiation necrosis and malignant glioma in rat models using diffusion tensor MR imaging

摘要: Standard MRI cannot distinguish between radiation necrosis and tumor progression; however, this distinction is critical in the assessment of response to therapy. In study, one delayed model (dose, 40 Gy; field, 10 × 10 mm2; n = 13) two orthotopic glioma models rats (9L gliosarcoma, n =8; human xenografts, n = 5) were compared using multiple diffusion tensor imaging (DTI) indices. A visible isotropic apparent coefficient (ADC) pattern was observed lesion due necrosis, which consisted a hypointense central zone hyperintense peripheral zone. There significantly lower ADC, parallel diffusivity, perpendicular diffusivity necrotic than (all P < 0.001). When radiation-induced with viable tumor, had ADC 9L gliosarcoma xenografts (both P < 0.01) zone, fractional anisotropy (P = 0.005) (P = 0.012) Histological analysis revealed parenchymal coagulative damaged vessels reactive astrogliosis These data suggest that qualitative quantitative DTI maps can provide useful information by glioma.