Yerba Mate Stimulates Mitochondrial Biogenesis and Thermogenesis in High-Fat-Diet-Induced Obese Mice.

摘要: Scope The potential effects of yerba mate (YM) on mitochondrial biogenesis and thermogenesis are evaluated. Methods results in vitro YM respiration assessed C2C12 cells. expression genes related to analyzed by quantitative PCR. vivo experiments performed mice fed a high-fat diet (HFD) treated with extract. Indirect calorimetry was performed, the proteins biogenesis, thermogenesis, de novo lipogenesis is determined PCR western blot. Our data indicate that increases mtDNA copy number as well spare respiratory capacity coupling efficiency. gene profile reinforces this evidence, indicating modulation downstream Ampk. In vivo, it found partially prevents diet-induced obesity increasing energy expenditure enhancing via AMPK/SIRT1/PGC1α pathway. Conclusions stimulates mitochondriogenesis Ucp expression, leading an increase dissipation. These may help better understand use for treatment.