Crosstalk between Regulatory T Cells and Tumor-Associated Dendritic Cells Negates Anti-tumor Immunity in Pancreatic Cancer

作者: Jung-Eun Jang , Cristina H. Hajdu , Caroline Liot , George Miller , Michael L. Dustin

DOI: 10.1016/J.CELREP.2017.06.062

关键词:

摘要: … of Treg cells in PDA is poorly understood. Here, we demonstrate that Treg cell ablation is sufficient to evoke effective anti-tumor immune response in early and advanced pancreatic …

参考文章(55)
Serena Lunardi, Su Yin Lim, Ruth J Muschel, Thomas B Brunner, IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer OncoImmunology. ,vol. 4, pp. 1- 3 ,(2015) , 10.1080/2162402X.2015.1027473
Vijay Shankaran, Hiroaki Ikeda, Allen T. Bruce, J. Michael White, Paul E. Swanson, Lloyd J. Old, Robert D. Schreiber, IFNγ, and lymphocytes prevent primary tumour development and shape tumour immunogenicity Nature. ,vol. 410, pp. 1107- 1111 ,(2001) , 10.1038/35074122
Nikhil S. Joshi, Elliot H. Akama-Garren, Yisi Lu, Da-Yae Lee, Gregory P. Chang, Amy Li, Michel DuPage, Tuomas Tammela, Natanya R. Kerper, Anna F. Farago, Rebecca Robbins, Denise M. Crowley, Roderick T. Bronson, Tyler Jacks, Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses Immunity. ,vol. 43, pp. 579- 590 ,(2015) , 10.1016/J.IMMUNI.2015.08.006
Albert Lo, Liang-Chuan S. Wang, John Scholler, James Monslow, Diana Avery, Kheng Newick, Shaun O'Brien, Rebecca A. Evans, David J. Bajor, Cynthia Clendenin, Amy C. Durham, Elizabeth L. Buza, Robert H. Vonderheide, Carl H. June, Steven M. Albelda, Ellen Puré, Tumor-promoting desmoplasia is disrupted by depleting FAP-expressing stromal cells Cancer Research. ,vol. 75, pp. 2800- 2810 ,(2015) , 10.1158/0008-5472.CAN-14-3041
Hiroyoshi Nishikawa, Shimon Sakaguchi, Regulatory T cells in tumor immunity International Journal of Cancer. ,vol. 127, pp. 759- 767 ,(2010) , 10.1002/IJC.25429
Lisa M. Coussens, Dirk G. Brockstedt, Thomas W. Dubensky, Raffit Hassan, Todd D. Armstrong, Elizabeth M. Jaffee, Bridget P. Keenan, Yvonne Saenger, Michel I. Kafrouni, Ashley Leubner, Peter Lauer, Anirban Maitra, Agnieszka A. Rucki, Andrew J. Gunderson, A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice Gastroenterology. ,vol. 146, pp. 1784- 1794 ,(2014) , 10.1053/J.GASTRO.2014.02.055
Joseph Markowitz, Taylor R. Brooks, Megan C. Duggan, Bonnie K. Paul, Xueliang Pan, Lai Wei, Zachary Abrams, Eric Luedke, Gregory B. Lesinski, Bethany Mundy-Bosse, Tanios Bekaii-Saab, William E. Carson, Patients with pancreatic adenocarcinoma exhibit elevated levels of myeloid-derived suppressor cells upon progression of disease Cancer Immunology, Immunotherapy. ,vol. 64, pp. 149- 159 ,(2015) , 10.1007/S00262-014-1618-8
Madhav D. Sharma, Babak Baban, Phillip Chandler, De-Yan Hou, Nagendra Singh, Hideo Yagita, Miyuki Azuma, Bruce R. Blazar, Andrew L. Mellor, David H. Munn, Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase Journal of Clinical Investigation. ,vol. 117, pp. 2570- 2582 ,(2007) , 10.1172/JCI31911
Shohei Hori, Takashi Nomura, Shimon Sakaguchi, Control of Regulatory T Cell Development by the Transcription Factor Foxp3 Science. ,vol. 299, pp. 1057- 1061 ,(2003) , 10.1126/SCIENCE.1079490