Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
作者： Michael K Cooper , Jeffery A Porter , Keith E Young , Philip A Beachy
DOI: 10.1126/SCIENCE.280.5369.1603
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摘要: Veratrum alkaloids and distal inhibitors of cholesterol biosynthesis have been studied for more than 30 years as potent teratogens capable inducing cyclopia other birth defects. Here, it is shown that these compounds specifically block the Sonic hedgehog (Shh) signaling pathway. These did not prevent sterol modification Shh during autoprocessing but rather inhibited response target tissues to Shh, possibly acting through sensing domain within Patched protein regulator response.
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