CD4+ T Cell-Mimicking Nanoparticles Broadly Neutralize HIV-1 and Suppress Viral Replication through Autophagy.

作者: Gang Zhang , Grant R. Campbell , Qiangzhe Zhang , Erin Maule , Jonathan Hanna

DOI: 10.1128/MBIO.00903-20

关键词:

摘要: Therapeutic strategies that provide effective and broad‐spectrum neutralization against HIV-1 infection are highly desirable. Here, we investigate the potential of nanoengineered CD4+ …

参考文章(79)
A Adachi, H E Gendelman, S Koenig, T Folks, R Willey, A Rabson, M A Martin, Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. Journal of Virology. ,vol. 59, pp. 284- 291 ,(1986) , 10.1128/JVI.59.2.284-291.1986
Grant R. Campbell, Pratima Rawat, Rachel S. Bruckman, Stephen A. Spector, Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration PLOS Pathogens. ,vol. 11, pp. e1005018- ,(2015) , 10.1371/JOURNAL.PPAT.1005018
Lakshmi Narashimhan Ramana, Shilpee Sharma, Swaminathan Sethuraman, Udaykumar Ranga, Uma Maheswari Krishnan, Stealth anti-CD4 conjugated immunoliposomes with dual antiretroviral drugs--modern Trojan horses to combat HIV European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 89, pp. 300- 311 ,(2015) , 10.1016/J.EJPB.2014.11.021
Guido Kroemer, Beth Levine, Autophagic cell death: the story of a misnomer Nature Reviews Molecular Cell Biology. ,vol. 9, pp. 1004- 1010 ,(2008) , 10.1038/NRM2529
T. Zhou, I. Georgiev, X. Wu, Z.-Y. Yang, K. Dai, A. Finzi, Y. Do Kwon, J. F. Scheid, W. Shi, L. Xu, Y. Yang, J. Zhu, M. C. Nussenzweig, J. Sodroski, L. Shapiro, G. J. Nabel, J. R. Mascola, P. D. Kwong, Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01. Science. ,vol. 329, pp. 811- 817 ,(2010) , 10.1126/SCIENCE.1192819
Lakshmi Narashimhan Ramana, Shilpee Sharma, Swaminathan Sethuraman, Udaykumar Ranga, Uma Maheswari Krishnan, Evaluation of chitosan nanoformulations as potent anti-HIV therapeutic systems Biochimica et Biophysica Acta (BBA) - General Subjects. ,vol. 1840, pp. 476- 484 ,(2014) , 10.1016/J.BBAGEN.2013.10.002
Peter D. Kwong, John R. Mascola, Gary J. Nabel, Mining the B cell repertoire for broadly neutralizing monoclonal antibodies to HIV-1. Cell Host & Microbe. ,vol. 6, pp. 292- 294 ,(2009) , 10.1016/J.CHOM.2009.09.008
Andrea Calcagno, Giovanni Di Perri, Stefano Bonora, Pharmacokinetics and pharmacodynamics of antiretrovirals in the central nervous system. Clinical Pharmacokinectics. ,vol. 53, pp. 891- 906 ,(2014) , 10.1007/S40262-014-0171-0
Grant R Campbell, Stephen A Spector, Inhibition of human immunodeficiency virus type-1 through autophagy. Current Opinion in Microbiology. ,vol. 16, pp. 349- 354 ,(2013) , 10.1016/J.MIB.2013.05.006