β‐cell differentiation status in type 2 diabetes

作者: Nicola Jeffery , Lorna W. Harries

DOI: 10.1111/DOM.12778

关键词:

摘要: Type 2 diabetes (T2D) affects 415 million people worldwide and is characterized by chronic hyperglycaemia and insulin resistance, progressing to insufficient insulin production, as a result of β‐cell failure. Over time, chronic hyperglycaemia can ultimately lead to loss of β‐cell function, leaving patients insulin‐dependent. Until recently the loss of β‐cell mass seen in T2D was considered to be the result of increased rates of apoptosis; however, it has been proposed that apoptosis alone cannot account for the extent of β‐cell mass loss seen in the …

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