Epidermal growth factor receptor and metastatic colorectal cancer: Insights into target therapies
作者： Ramon Andrade de Mello , Andrea Marin Marques , António Araújo , None
关键词:
摘要: Colorectal cancer (CRC) has high incidence and mortality worldwide. In 2012, CRC was the second most prevalent among males (9%) third females (8%). recent decades, standard chemotherapies protocols combining 5-fluorouracil, leucovorin, irinotecan oxaliplatin were important for improve survival in this set of patients. Further, biological drugs throughout epidermal growth factor receptor (EGFR) pathways showed interesting results metastatic disease (mCRC) control when association to chemotherapy regimens. Cetuximab panitumumab are two cornerstones mCRC treatment both approved Europe United States based on previous phase III trials. This paper will briefly summarize those anti-EGFR therapies framework discusses some issues regard.
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sci-hub.st 参考文章(24)
Andreas Gschwind, Oliver M. Fischer, Axel Ullrich, The discovery of receptor tyrosine kinases: targets for cancer therapy. Nature Reviews Cancer. ,vol. 4, pp. 361- 370 ,(2004) , 10.1038/NRC1360
Sun Young Kim, Eun Kyung Shim, Hyun Yang Yeo, Ji Yeon Baek, Yong Sang Hong, Dae Yong Kim, Tae Won Kim, Jee Hyun Kim, Seock-Ah Im, Kyung Hae Jung, Hee Jin Chang, KRAS Mutation Status and Clinical Outcome of Preoperative Chemoradiation With Cetuximab in Locally Advanced Rectal Cancer: A Pooled Analysis of 2 Phase II Trials International Journal of Radiation Oncology Biology Physics. ,vol. 85, pp. 201- 207 ,(2013) , 10.1016/J.IJROBP.2012.03.048
R. E. Shackelford, N. A. Whitling, P. McNab, S. Japa, D. Coppola, KRAS Testing: A Tool for the Implementation of Personalized Medicine Genes & Cancer. ,vol. 3, pp. 459- 466 ,(2012) , 10.1177/1947601912460547
J. Randolph Hecht, Edith Mitchell, Tarek Chidiac, Carroll Scroggin, Christopher Hagenstad, David Spigel, John Marshall, Allen Cohn, David McCollum, Philip Stella, Robert Deeter, Seta Shahin, Rafael G. Amado, A Randomized Phase IIIB Trial of Chemotherapy, Bevacizumab, and Panitumumab Compared With Chemotherapy and Bevacizumab Alone for Metastatic Colorectal Cancer Journal of Clinical Oncology. ,vol. 27, pp. 672- 680 ,(2009) , 10.1200/JCO.2008.19.8135
Thomas H. Cartwright, Treatment decisions after diagnosis of metastatic colorectal cancer. Clinical Colorectal Cancer. ,vol. 11, pp. 155- 166 ,(2012) , 10.1016/J.CLCC.2011.11.001
Sandra Misale, Rona Yaeger, Sebastijan Hobor, Elisa Scala, Manickam Janakiraman, David Liska, Emanuele Valtorta, Roberta Schiavo, Michela Buscarino, Giulia Siravegna, Katia Bencardino, Andrea Cercek, Chin-Tung Chen, Silvio Veronese, Carlo Zanon, Andrea Sartore-Bianchi, Marcello Gambacorta, Margherita Gallicchio, Efsevia Vakiani, Valentina Boscaro, Enzo Medico, Martin Weiser, Salvatore Siena, Federica Di Nicolantonio, David Solit, Alberto Bardelli, Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer Nature. ,vol. 486, pp. 532- 536 ,(2012) , 10.1038/NATURE11156
Jim Cassidy, Stephen Clarke, Eduardo Díaz-Rubio, Werner Scheithauer, Arie Figer, Ralph Wong, Sheryl Koski, Mikhail Lichinitser, Tsai-Shen Yang, Fernando Rivera, Felix Couture, Florin Sirzén, Leonard Saltz, Randomized Phase III Study of Capecitabine Plus Oxaliplatin Compared With Fluorouracil/Folinic Acid Plus Oxaliplatin As First-Line Therapy for Metastatic Colorectal Cancer Journal of Clinical Oncology. ,vol. 26, pp. 2006- 2012 ,(2008) , 10.1200/JCO.2007.14.9898
Eric Van Cutsem, Claus-Henning Köhne, Erika Hitre, Jerzy Zaluski, Chung-Rong Chang Chien, Anatoly Makhson, Geert D'Haens, Tamás Pintér, Robert Lim, György Bodoky, Jae Kyung Roh, Gunnar Folprecht, Paul Ruff, Christopher Stroh, Sabine Tejpar, Michael Schlichting, Johannes Nippgen, Philippe Rougier, Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. The New England Journal of Medicine. ,vol. 360, pp. 1408- 1417 ,(2009) , 10.1056/NEJMOA0805019
Jean-Yves Douillard, Salvatore Siena, James Cassidy, Josep Tabernero, Ronald Burkes, Mario Barugel, Yves Humblet, György Bodoky, David Cunningham, Jacek Jassem, Fernando Rivera, Ilona Kocákova, Paul Ruff, Maria Błasińska-Morawiec, Martin Šmakal, Jean-Luc Canon, Mark Rother, Kelly S Oliner, Michael Wolf, Jennifer Gansert, None, Randomized, Phase III Trial of Panitumumab With Infusional Fluorouracil, Leucovorin, and Oxaliplatin (FOLFOX4) Versus FOLFOX4 Alone As First-Line Treatment in Patients With Previously Untreated Metastatic Colorectal Cancer: The PRIME Study Journal of Clinical Oncology. ,vol. 28, pp. 4697- 4705 ,(2010) , 10.1200/JCO.2009.27.4860
Jeffrey B Hoag, Aimel Azizi, Timothy J Doherty, Jason Lu, Rudolph E Willis, Mark E Lund, Association of cetuximab with adverse pulmonary events in cancer patients: a comprehensive review Journal of Experimental & Clinical Cancer Research. ,vol. 28, pp. 113- 113 ,(2009) , 10.1186/1756-9966-28-113