UCA1 overexpression predicts clinical outcome of patients with ovarian cancer receiving adjuvant chemotherapy
作者： Ling Zhang , Xili Cao , Liqian Zhang , Xuelin Zhang , Haihui Sheng
DOI: 10.1007/S00280-016-2963-4
关键词:
摘要: Urothelial carcinoma associated 1 (UCA1) functions as an oncogene, which promotes cancer cell proliferation, invasion, and metastasis, is responsible for drug resistance. This study aimed to determine the expression level of UCA1 in ovarian further investigate its clinical significance. The levels normal ovaries were determined by quantitative real-time PCR. relationship between features prognostic value overall survival examined. tissues was significantly upregulated compared with tissues. High related lymph node FIGO stage, response chemotherapy. Kaplan–Meier analysis demonstrated that high poorer patients cancer. Cox proportional hazards showed independent marker poor outcome. effect remained significant stratification analysis. Our findings provided first evidence may serve indicator chemotherapy prognosis play important role progression
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