Prognostic value of long non-coding RNA UCA1 in human solid tumors

摘要: // Fang-teng Liu 1 , Pei-qian Zhu Hong-liang Luo Yi Zhang Cheng Qiu Department of General Surgery, the Second Affiliated Hospital Nanchang University, 330000, Jiangxi Province, P. R. China Correspondence to: Zhu, email: 3141723790@qq.com Luo, 517295653@qq.com Keywords: long non-coding RNA, UCA1, carcinoma, prognosis, meta-analysis Received: April 24, 2016      Accepted: July 28, Published: August 09, 2016 ABSTRACT Background: Numerous studies have shown that expression UCA1 was aberrantly upregulated in various cancer types. High reported to be associated with unfavorable prognosis patients. Results: A total 1240 patients from 15 articles were included. The results indicated a significantly shorter OS observed high level (HR = 1.71, 95% CI: 1.43–1.99), subgroup analysis, association also cancers digestive system 2.12, 1.59–2.66). Statistical significance stratified by type, cut-off value, analysis type and sample size. Furthermore, poorer DFS 2.54; 1.09–4.00). Additionally, pooled odds ratios (ORs) showed increased related positive lymph node metastasis (OR 2.98, 2.06–4.30), distant 3.14, 1.77–5.58) poor clinical stage 2.76, 2.08–3.68). Materials Methods: comprehensive retrieval conducted multiple databases, including PubMed, Embase, Web Science CNKI. We collected relevant explore between levels prognosis. Conclusions: outcome. could serve as novel biomarker for might potential predictive factor clinicopathological characteristics cancers. Further should performed verify utility human solid tumors.