Taurine inhibits ischemia/reperfusion-induced compartment syndrome in rabbits.

摘要: Aim: To investigate effects of taurine on ischemia/reperfusion (I/R)-induced compartment syndrome in rabbit hind limbs. Methods: Rabbits underwent femoral artery occlusion after ligation branches from terminal aorta to artery. After a 7-h ischemia, reperfusion was established with the use heparinized polyethylene shunts. received (1 g/kg) or normal saline (control) by iv infusion 10 min before shunt placement. During reperfusion, anterior pressure (ACP) monitored continuously left lower extremity. Gastrocnemius muscle triphenyltetrazolium chloride (TTC) level, content and myeloperoxidase activity were assayed. Oxidative stress induced vitro gastrocnemius slices free radical generating systems (FRGS), malondialdehyde measured presence absence taurine. Results: 7 h none parameters that we different those except TTC reduction decreased 80%. In control group, 2 ACP increased 4.5-fold, reduced 33%. taurine-treated animals, at mean arterial blood heart rate increased, 6% 10%. 39%, edema 16%, 150%, lactate dehydrogenase 36% compared group. Plasma 70% 88%, respectively. plasma conjugated diene 38% 23%, respectively, 22% 30%, respectively At 3.5-fold animals. study, incubated hypochlorous acid dose-dependent manner, but there no change when hydrogen peroxide xanthine oxidase. Conclusion: Treatment inhibited I/R-induced least part attenuating oxidative injury I/R, suggesting clinical application might be new strategy for prevention treatment syndrome.