Immunopathology of the Inner Ear: An Update

摘要: We have reviewed the events of an inner-ear immune response. The perilymph contains antibody, presumably derived from systemic circulation and CSF, which would allow for neutralization help with opsonization complement fixation. endolymphatic sac immunocompetent cells capable processing presenting viral or bacterial antigen, potentiating response, attacking invaders directly infected cells, developing immunoglobulin responses in situ. early release mediators such as IL-2 likely emanate result potentiation regulation response may assist changes SMV, including expression ICAM-1, aid egress circulation. PMNs arrive first, followed by T B secretion specific antibody a relatively late event. Concomitant increase cellular constituents is formation dense extracellular matrix. inner ear appears to remarkable difficulty clearing this matrix, ultimately resulting ossification. unfortunately deleterious ear, degeneration organ Corti, stria vascularis, spiral ganglion. Hearing loss consistently seen following sterile virally induced labyrinthitis. also be target autoimmune disease. While damage has been described part non-organ-specific disease, disease against hearing apparatus likely. Experimental paradigms allowed alterations both afferent efferent limbs response; ultimately, hope that we can alter course subsequent patients.