Role of Human Mast Cells and Basophils in Bronchial Asthma
作者： Gianni Marone , Massimo Triggiani , Arturo Genovese , Amato De Paulis
DOI: 10.1016/S0065-2776(05)88004-6
关键词:
摘要: Mast cells and basophils are the only expressing tetrameric (alphabetagamma2) structure of high affinity receptor for IgE (FcepsilonRI) synthesizing histamine in humans. Human FcepsilonRI+ conventionally considered primary effector bronchial asthma. There is now compelling evidence that these differ immunologically, biochemically, pharmacologically, which suggests they might play distinct roles appearance fluctuation asthma phenotype. Recent data have revealed complexity involvement human mast shed light on control recruitment activation different lung compartments. Preliminary not always be detrimental but, under some circumstances, exert a protective effect by modulating certain aspects innate acquired immunity allergic inflammation.
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