Basophils: historical reflections and perspectives.

摘要: Basophils were discovered by Paul Ehrlich in 1879 and account for less than 1% of blood leukocytes, which suggests a tightly controlled regulation basopoiesis. The conservation basophils wide spectrum the animal kingdom non-redundant role innate adaptive immunity. In early 1990s, it was demonstrated that murine human synthesize interleukin (IL)-4 IL-13, thereby suggesting these cells are important Th2 polarization IgE synthesis. Human also IL-3, VEGFs other pro-angiogenic molecules. Recently, various groups have introduced use basophil-depleting antibodies or developed transgenic mice constitutively lack more 90%. These models highlighted previously unrecognized roles basophils, distinct from those played mast cells, Although physiologic remains unknown, there is now compelling evidence despite their small numbers peripheral inflamed tissues, critically involved immunologic disorders (allergic, autoimmune infectious diseases, immunodeficiencies cancer). It not inconceivable and/or products could be promising therapeutic targets such disorders.