Neoadjuvant Treatment With Single-Agent Cetuximab Followed by 5-FU, Cetuximab, and Pelvic Radiotherapy: A Phase II Study in Locally Advanced Rectal Cancer

作者: Federica Bertolini , Silvana Chiara , Carmelo Bengala , Paolo Antognoni , Cristina Dealis

DOI: 10.1016/J.IJROBP.2008.04.065

关键词:

摘要: PURPOSE: Preoperative chemoradiotherapy followed by surgery represents the standard of care for locally advanced rectal cancer (LARC). Cetuximab has proved activity in advanced …

参考文章(32)
Claus Rödel, Dirk Arnold, Matthias Hipp, Torsten Liersch, Kathrin Dellas, Igors Iesalnieks, Robert Michael Hermann, Florian Lordick, Axel Hinke, Werner Hohenberger, Rolf Sauer, Phase I-II Trial of Cetuximab, Capecitabine, Oxaliplatin, and Radiotherapy as Preoperative Treatment in Rectal Cancer International Journal of Radiation Oncology Biology Physics. ,vol. 70, pp. 1081- 1086 ,(2008) , 10.1016/J.IJROBP.2007.07.2356
Jordi Giralt, Manuel de las Heras, Laura Cerezo, Aranzazu Eraso, Edurado Hermosilla, Dolores Velez, Juan Lujan, Eloi Espin, Jose Rossello, Joaquin Majó, Sergi Benavente, Manel Armengol, I. de Torres, The expression of epidermal growth factor receptor results in a worse prognosis for patients with rectal cancer treated with preoperative radiotherapy: a multicenter, retrospective analysis Radiotherapy and Oncology. ,vol. 74, pp. 101- 108 ,(2005) , 10.1016/J.RADONC.2004.12.021
Federica Bertolini, Carmelo Bengala, Luisa Losi, Maria Pagano, Francesco Iachetta, Cristina Dealis, Gordana Jovic, Roberta Depenni, Sandra Zironi, Anna Maria Falchi, Gabriele Luppi, Pier Franco Conte, None, Prognostic and predictive value of baseline and posttreatment molecular marker expression in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy. International Journal of Radiation Oncology Biology Physics. ,vol. 68, pp. 1455- 1461 ,(2007) , 10.1016/J.IJROBP.2007.02.018
Matilde Navarro, Emma Dotor, Fernando Rivera, Pedro Sánchez-Rovira, Maria Eugenia Vega-Villegas, Andrés Cervantes, José Luis García, Manel Gallén, Enrique Aranda, A Phase II study of preoperative radiotherapy and concomitant weekly irinotecan in combination with protracted venous infusion 5-fluorouracil, for resectable locally advanced rectal cancer International Journal of Radiation Oncology*Biology*Physics. ,vol. 66, pp. 201- 205 ,(2006) , 10.1016/J.IJROBP.2006.04.007
Jean-François Bosset, Gilles Calais, Laurent Mineur, Philippe Maingon, Ljiljana Radosevic-Jelic, Alain Daban, Etienne Bardet, Alexander Beny, Antoine Briffaux, Laurence Collette, Enhanced Tumorocidal Effect of Chemotherapy With Preoperative Radiotherapy for Rectal Cancer: Preliminary Results—EORTC 22921 Journal of Clinical Oncology. ,vol. 23, pp. 5620- 5627 ,(2005) , 10.1200/JCO.2005.02.113
Lorena Losi, Gabriele Luppi, Margherita Gavioli, Francesco Iachetta, Federica Bertolini, Roberto D’Amico, Gordana Jovic, Filippo Bertoni, Anna Maria Falchi, Pier Franco Conte, None, Prognostic value of Dworak grade of regression (GR) in patients with rectal carcinoma treated with preoperative radiochemotherapy International Journal of Colorectal Disease. ,vol. 21, pp. 645- 651 ,(2006) , 10.1007/S00384-005-0061-X
Leonard B. Saltz, Donna Niedzwiecki, Donna Hollis, Richard M. Goldberg, Alexander Hantel, James P. Thomas, Anthony L.A. Fields, Robert J. Mayer, Irinotecan Fluorouracil Plus Leucovorin Is Not Superior to Fluorouracil Plus Leucovorin Alone As Adjuvant Treatment for Stage III Colon Cancer: Results of CALGB 89803 Journal of Clinical Oncology. ,vol. 25, pp. 3456- 3461 ,(2007) , 10.1200/JCO.2007.11.2144
J Gerard, P Romestaing, F Bonnetain, T Conroy, O Bouche, M Closon Desjardins, M Untereiner, B Leduc, E Francois, L Bedenne, None, Preoperative Chemoradiotherapy (CT-RT) Improves Local Control in T3-4 Rectal Cancers: Results of the FFCD 9203 Randomized Trial International Journal of Radiation Oncology Biology Physics. ,vol. 63, ,(2005) , 10.1016/J.IJROBP.2005.07.010
Jean-Pascal Machiels, Selda Aydin, Marie-Alix Bonny, Fatima Hammouch, Christine Sempoux, What is the best way to predict disease-free survival after preoperative radiochemotherapy for rectal cancer patients: tumor regression grading, nodal status, or circumferential resection margin invasion? Journal of Clinical Oncology. ,vol. 24, pp. 1319- 1319 ,(2006) , 10.1200/JCO.2005.05.0963
Mohammed Mohiuddin, Kathryn Winter, Edith Mitchell, Nader Hanna, Albert Yuen, Charles Nichols, Robert Shane, Cherie Hayostek, Christopher Willett, Randomized Phase II Study of Neoadjuvant Combined-Modality Chemoradiation for Distal Rectal Cancer: Radiation Therapy Oncology Group Trial 0012 Journal of Clinical Oncology. ,vol. 24, pp. 650- 655 ,(2006) , 10.1200/JCO.2005.03.6095