Updated Three-Stage Model for the Peopling of the Americas

摘要: Background We re-assess support for our three stage model the peopling of Americas in light a recent report that identified nine non-Native American mitochondrial genome sequences should not have been included initial analysis. Removal these results elimination an early (i.e. ∼40,000 years ago) expansion signal we had proposed proto-Amerind population. Methodology/Findings Bayesian skyline plot analysis new dataset Native coding genomes confirms absence population and allows us to reduce variation around estimate New World founder size. In addition, genetic variants define haplogroups are used amount time required between divergence proto-Amerinds from Asian gene pool into World. Conclusions/Significance The period isolation generation haplogroup-defining makes existence stages colonization logical conclusion. Thus, remains important useful working hypothesis researchers interested processes colonization.