Gas6/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma patients
作者： Ju Han , Rui Tian , Bicheng Yong , Canqiao Luo , Pingxian Tan
DOI: 10.1016/J.BBRC.2013.05.019
关键词:
摘要: Dysregulation of the receptor tyrosine kinase Axl and its ligand Gas6 has been shown to promote multiple tumorigenic processes, as well correlate with worse prognosis in many different tumor types. However, studies expression function osteosarcoma have rarely reported. In this study, we report that activated is highly expressed cells, significantly correlated recurrence lung metastasis patients. High was an independent predictor for osteosarcoma. Additionally, confirmed a strong positive correlation between P-Axl MMP-9 those cell lines MG63 U2OS, 200 ng/ml rhGas6 could cause obvious increase within 30 min, consistent P-AKT. both lines, by protect cells from apoptosis caused serum starvation, cells' migration invasion vitro. Together previous data, these suggest participate progression resisting promoting their invasion, which may be linked MMP-9. mechanism, AKT signaling pathway contribute rather than ERK pathway.
elsevier.com
sci-hub.se 参考文章(23)
Tetsuhiro Nakano, Masachika Tani, Yasunori Ishibashi, Kenji Kimura, Yong-Bum Park, Natsuko Imaizumi, Hiroyuki Tsuda, Kazuhiko Aoyagi, Hiroki Sasaki, Susumu Ohwada, Jun Yokota, Biological properties and gene expression associated with metastatic potential of human osteosarcoma Clinical & Experimental Metastasis. ,vol. 20, pp. 665- 674 ,(2003) , 10.1023/A:1027355610603
Rachel M.A. Linger, Amy K. Keating, H. Shelton Earp, Douglas K. Graham, TAM Receptor Tyrosine Kinases: Biologic Functions, Signaling, and Potential Therapeutic Targeting in Human Cancer Advances in Cancer Research. ,vol. 100, pp. 35- 83 ,(2008) , 10.1016/S0065-230X(08)00002-X
Emmanouil S. Papadakis, Monika A. Cichoń, Jashmin J. Vyas, Nakul Patel, Lucy Ghali, Rino Cerio, Alan Storey, Edel A. O'Toole, Axl Promotes Cutaneous Squamous Cell Carcinoma Survival through Negative Regulation of Pro-Apoptotic Bcl-2 Family Members Journal of Investigative Dermatology. ,vol. 131, pp. 509- 517 ,(2011) , 10.1038/JID.2010.326
KY Tai, YS Shieh, CS Lee, SG Shiah, Cheng-Wen Wu, None, Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-κB and Brg-1 Oncogene. ,vol. 27, pp. 4044- 4055 ,(2008) , 10.1038/ONC.2008.57
Trevor N Stitt, Greg Conn, Martin Goret, Cary Lai, Joanne Bruno, Czeslaw Radzlejewski, Karen Mattsson, John Fisher, David R Gies, Pamela F Jones, Piotr Masiakowski, Terence E Ryan, Nancy J Tobkes, D.H Chen, Peter S DiStefano, George L Long, Claudio Basilico, Mitchell P Goldfarb, Greg Lemke, David J Glass, George D Yancopoulos, The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases Cell. ,vol. 80, pp. 661- 670 ,(1995) , 10.1016/0092-8674(95)90520-0
Jonathan Gill, Manpreet K. Ahluwalia, David Geller, Richard Gorlick, New targets and approaches in osteosarcoma Pharmacology & Therapeutics. ,vol. 137, pp. 89- 99 ,(2013) , 10.1016/J.PHARMTHERA.2012.09.003
Reuben J. Shaw, J.Guillermo Paez, Marcello Curto, Ann Yaktine, Wendy Morse Pruitt, Ichiko Saotome, John P. O'Bryan, Vikas Gupta, Nancy Ratner, Channing J. Der, Tyler Jacks, Andrea I. McClatchey, The Nf2 Tumor Suppressor, Merlin, Functions in Rac-Dependent Signaling Developmental Cell. ,vol. 1, pp. 63- 72 ,(2001) , 10.1016/S1534-5807(01)00009-0
Anupam Verma, Steven L. Warner, Hariprasad Vankayalapati, David J. Bearss, Sunil Sharma, Targeting Axl and Mer kinases in cancer. Molecular Cancer Therapeutics. ,vol. 10, pp. 1763- 1773 ,(2011) , 10.1158/1535-7163.MCT-11-0116
Xianzhou Song, Hua Wang, Craig D Logsdon, Asif Rashid, Jason B Fleming, James L Abbruzzese, Henry F Gomez, Douglas B Evans, Huamin Wang, None, Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma. Cancer. ,vol. 117, pp. 734- 743 ,(2011) , 10.1002/CNCR.25483
M-H Yang, S-Y Chang, S-H Chiou, C-J Liu, C-W Chi, P-M Chen, S-C Teng, K-J Wu, Overexpression of NBS1 induces epithelial-mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancer. Oncogene. ,vol. 26, pp. 1459- 1467 ,(2007) , 10.1038/SJ.ONC.1209929