CYP2E1 Genetic Polymorphisms and Risk of Nasopharyngeal Carcinoma in Taiwan

摘要: Background: Nasopharyngeal carcinoma occurs disproportionately among individuals of Chinese descent. The cytochrome P450 2E1 enzyme (CYP2E1) is known to activate nitrosamines and other carcinogens that are possibly involved in the development this disease. Certain alleles CYP2E1 gene thought be more highly expressed than others, their distribution varies between Asian Caucasian populations. We conducted a case-control study investigate whether such variations affect risk developing nasopharyngeal cancer. Methods: Three hundred sixty-four patients with (96% 378 eligible patients) 320 control subjects (86% 374 subjects) were studied. A factor questionnaire was administered participants assess factors postulated linked carcinoma. Peripheral blood obtained from all DNA purified nucleated cells. polymerase chain reaction-based restriction fragment length polymorphism assay used enzymes Rsa I Dra detect wild-type variant forms gene. Results: Individuals homozygous for an allele detected by digestion (c2 allele) found have increased (relative [RR] = 2.6; 95% confidence interval [CI] 1.2-5.7); effect limited non-smokers (RR 9.3; CI 2.7-32) not affected alcohol consumption. Conclusions: Our findings suggest genotype determinant risk.