Chronic whiplash symptoms are related to altered regional cerebral blood flow in the resting state
作者： Clas Linnman , Lieuwe Appel , Anne Söderlund , Örjan Frans , Henry Engler
DOI: 10.1016/J.EJPAIN.2008.03.001
关键词:
摘要: The neural pathogenic mechanisms involved in mediating chronic pain and whiplash associated disorders (WAD) after rear impact car collisions are largely unknown. This study’s first objective was to compare resting state regional cerebral blood flow (rCBF) by means of positron emission tomography with 15O labelled water 21 WAD patients 18 healthy, pain-free controls. A second investigate the relations between brain areas altered rCBF experience, somatic symptoms, posttraumatic stress symptoms personality traits patient group. Patients had heightened bilaterally posterior parahippocampal cingulate gyri, right thalamus medial prefrontal gyrus as well lowered tempero-occipital compared healthy group correlated neck disability ratings. We thus suggest an involvement cingulate, gyri speculate that alterations linked increased self-relevant evaluation stress.
sci-hub.se 参考文章(60)
Matthew Brett, Jean-Luc Anton, Romain Valabregue, Jean-Baptiste Poline, Region of interest analysis using an SPM toolbox NeuroImage. ,vol. 16, pp. 497- ,(2002)
Charles D. Spielberger, Richard L. Gorsuch, R. E. Lushene, Manual for the State-Trait Anxiety Inventory Consulting Psychologist. ,(1970)
Alexander Ploghaus, Charvy Narain, Christian F. Beckmann, Stuart Clare, Susanna Bantick, Richard Wise, Paul M. Matthews, J. Nicholas P. Rawlins, Irene Tracey, Exacerbation of Pain by Anxiety Is Associated with Activity in a Hippocampal Network The Journal of Neuroscience. ,vol. 21, pp. 9896- 9903 ,(2001) , 10.1523/JNEUROSCI.21-24-09896.2001
Michael D. Fox, Marcus E. Raichle, Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nature Reviews Neuroscience. ,vol. 8, pp. 700- 711 ,(2007) , 10.1038/NRN2201
Gustav Wik, Håkan Fischer, Björn Bragée, Marianne Kristianson, Mats Fredrikson, Retrosplenial cortical activation in the fibromyalgia syndrome Neuroreport. ,vol. 14, pp. 619- 621 ,(2003) , 10.1097/00001756-200303240-00019
Anne Söderlund, Eva Denison, Classification of patients with whiplash associated disorders (WAD): reliable and valid subgroups based on the Multidimensional Pain Inventory (MPI-S). European Journal of Pain. ,vol. 10, pp. 113- 119 ,(2006) , 10.1016/J.EJPAIN.2005.01.015
Arthur A. Rodriquez, Karen P. Barr, Stephen P. Burns, Whiplash: Pathophysiology, diagnosis, treatment, and prognosis Muscle & Nerve. ,vol. 29, pp. 768- 781 ,(2004) , 10.1002/MUS.20060
Israel Liberzon, Stephan F Taylor, Richard Amdur, Tara D Jung, Kenneth R Chamberlain, Satoshi Minoshima, Robert A Koeppe, Lorraine M Fig, Brain activation in PTSD in response to trauma-related stimuli. Biological Psychiatry. ,vol. 45, pp. 817- 826 ,(1999) , 10.1016/S0006-3223(98)00246-7
I. Bicik, B. P. Radanov, N. Schäfer, J. Dvorak, B. Blum, B. Weber, C. Burger, G. K. von Schulthess, A. Buck, PET with 18fluorodeoxyglucose and hexamethylpropylene amine oxime SPECT in late whiplash syndrome. Neurology. ,vol. 51, pp. 345- 350 ,(1998) , 10.1212/WNL.51.2.345
Mordechai Lorberboym, Ronit Gilad, Vladimir Gorin, Menahem Sadeh, Yair Lampl, Late whiplash syndrome: correlation of brain SPECT with neuropsychological tests and P300 event-related potential. Journal of Trauma-injury Infection and Critical Care. ,vol. 52, pp. 521- 526 ,(2002) , 10.1097/00005373-200203000-00017